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Shah, Samir K.
- Development and Validation of Analytical Methods for Simultaneous Estimation of Ferrous Ascorbate and Folic Acid in their Combined Dosage Form
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Authors
Affiliations
1 Sardar Patel College of Pharmacy, Vidhyanagar-Vadtal Road, Bakrol, Anand, Gujarat, IN
1 Sardar Patel College of Pharmacy, Vidhyanagar-Vadtal Road, Bakrol, Anand, Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 126-132Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Ferrous Ascorbate and Folic Acid in their combined dosage form using simultaneous equation and first order derivative method. In Simultaneous Equation method, Ferrous Ascorbate and Folic Acid were quantified using their absorptivity values of at selected wavelengths, i.e., 265 nm and 344 nm respectively. In First order Derivative method, Ferrous Ascorbate showed zero crossing point at 265.78 nm while Folic Acid showed zero crossing point at 280.34 nm. The dA/dλ was measured at 280.34 nm for Ferrous Ascorbate and 265.78 nm for Folic Acid and calibration curves were plotted as dA/dλ versus concentration, respectively. The method was found to be linear in the range of 10-80 μg/ml for Ferrous Ascorbate and 1-8 μg/ml for Folic Acid. The accuracy of the proposed methods was evaluated by recovery studies and good recovery results were obtained. The method was successfully applied for simultaneous determination of Ferrous Ascorbate and Folic Acid in combined dosage form.Keywords
Ferrous Ascorbate, Folic Acid, Vierodt’s Method, First Order Derivative Method.- Practical Implication of Stability Indicating Chromatographic Method for Estimation of Clomipramine Hydrochloride and its Related Substances from Capsule Dosage Form
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Authors
Affiliations
1 Department of Quality Assurance, Sardar Patel College of Pharmacy, Vidyanagar-Vadtal Road, Bakrol,(388315) Gujarat, IN
2 Department of Pharmacology, Sardar Patel College of Pharmacy, Vidyanagar-Vadtal Road, Bakrol,(388315) Gujarat, IN
1 Department of Quality Assurance, Sardar Patel College of Pharmacy, Vidyanagar-Vadtal Road, Bakrol,(388315) Gujarat, IN
2 Department of Pharmacology, Sardar Patel College of Pharmacy, Vidyanagar-Vadtal Road, Bakrol,(388315) Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 2 (2017), Pagination: 100-112Abstract
Clomipramine Hydrochloride is Tricyclic antidepressants (TCAs) drug which cause increased concentration of monoamines in the synaptic cleft, ultimately resulting in antidepressant effect. Literature reveals that all the reported methods are developed for estimation of Clomipramine Hydrochloride (CLH) in bulk and solid dosage form. My research is based on estimation of CLH and its related substances from capsule dosage form by HPLC method. A rapid, precise, selective and sensitive and accurate stability-indicating High Performance Liquid Chromatographic (HPLC) method for estimation of Clomipramine Hydrochloride and its related substances from capsule dosage form was developed and validated in the present work. The chromatographic separation was performed by using BDS Hypersil C18, 250 X 4.6 mm, 5 μ with 2 gm /L Tetra Butyl Ammonium Hydrogen Sulphate (TBAS) in Water (pH 2.5) : Methanol (40:60 v/v) mobile phase, at a flow rate of 1.2 ml/min. The method was validated according to ICH guidelines. The effluent was monitored using a UV detector set at 252nm. The retention time for CLH was observed at 6.2 min. Impurity spiked A, B, C, are retained at 7.8, and 9.4, 3.6, min respectively. The linearity of CLH and impurities was in the range of 1050 - 1800 μg/ml and 0.7 - 4.5μg/ml respectively. The developed method was successfully applied to the analysis of the drugs in their commercial dosage form.Keywords
Clomipramine Hydrochloride (CLH), Impurity, HPLC, Stability, Validation.- Evaluation of Antiurolithiatic Activity of Betula utilis in Rats Using Ethylene Glycol Model
Abstract Views :170 |
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Authors
Affiliations
1 Department of Pharmacology, Sardar Patel College of Pharmacy, Bakrol, Anand, Gujarat, IN
1 Department of Pharmacology, Sardar Patel College of Pharmacy, Bakrol, Anand, Gujarat, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 2 (2017), Pagination: 81-87Abstract
This study was aimed to evaluate the antiurolithiatic activity of alcoholic extract of Betula utilis in rats using ethylene glycol model. Standard drug used was Cystone. Healthy male Wistar rats weighing 180-200 g were selected. Ethylene glycol (0.75%) in drinking water was fed to all the groups (Groups II-VII) except normal control (Group I) for 28 days to induce urolithiasis for curative regimen (CR) and preventive regimen (PR). Groups III, IV served as CR and groups V, VI served as PR were treated with alcoholic extract of Betula utilis (250 and 500 mg/kg) Groups II and VII served as model control and standard (Cystone 750 mg/kg) respectively. Several parameters were used including urinary volume, urine pH, urine analysis, serum analysis, kidney homogenate and histopathology of kidney to assess the activity. The results indicated that the administration of alcoholic extract of Betula utilis to rats with ethylene glycol-induced lithiasis significantly reduced all the elevated biochemical parameters (calcium, phosphate, oxalate, creatinine, blood urea nitrogen and uric acid), restored the urine pH to normal and increased the urine volume significantly (p < 0.05) when compared to the model control. This study supports the usage of alcoholic extract of Betula utilis in urolithiasis.Keywords
Betula utilis, Ethylene Glycol, Cystone, Urolithiasis.- Daily Dose, in a Dot
Abstract Views :550 |
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Authors
Affiliations
1 Dept. of Pharmacology, Sardar Patel College of Pharmacy, Anand, IN
2 Dept. of Quality Assurance, Sardar Patel College of Pharmacy, Anand, IN
3 Principal, Dept. of Pharmacology, Sardar Patel College of Pharmacy, Anand, IN
1 Dept. of Pharmacology, Sardar Patel College of Pharmacy, Anand, IN
2 Dept. of Quality Assurance, Sardar Patel College of Pharmacy, Anand, IN
3 Principal, Dept. of Pharmacology, Sardar Patel College of Pharmacy, Anand, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 4 (2017), Pagination: 225-229Abstract
Iodine is a vital micronutrient required at all stages of life. It is concentrated in thyroid gland for the synthesis of thyroid hormones. Drinking water and crops grown in iodine rich soil are the most important sources of iodine. Leeching of iodine and ultra-violate radiation contribute to the development of iodine deficiency disorders (IDD). It mainly affects infant and children due to maternal iodine deficiency. A deficiency of thyroid hormone from any cause will lead to severe retardation of growth and maturation of almost all organ systems. In Asia, IDD is continuously increased from 4% to 50% among school children. Number of treatments are available for the IDD. However, the tribal population is considered to be one of the most disadvantaged groups in accessing the health care services and various other health policies. The Nashik based Neelvasant medical foundation & research centre established a new technique for the tribal women. They have made iodine patches in the form of different coloured bindis and distributed it among the tribal women. Around 80-90per cent of Indian women wear bindis. It is the best way to deal with the problem. The project is already started and ready to enter in its second phase. Where, larger number of population are covered.Keywords
Iodine, Iodine Deficiency Disease (IDD), Iodine Patches, Lifesaving Dot.References
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- A dOt with a mission, 07th August, 2017 http://www.the hindubusinessline.com/catalyst/a-dot-with-a-mission/article7085099.ece